Sage Bionetworks
Sage Bionetworks
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About this organization
Mission
Sage Bionetworks is a strategic research organization with a mission to coordinate and link academic and commercial biomedical researchers, patients and citizens through a Commons that represents a new paradigm for genomics intellectual property, researcher cooperation and contributor evolved resources. This mission has several interdependent themes, including: conducting research on network models of disease; building the computational platform for the Commons; and activating public engagement.
About
Research Communities and Challenges: Sage Bionetworks conducts research independently as well as with collaborators worldwide across a variety of disease areas. We work to redefine how complex biological data is gathered, shared and used through open systems, incentives, and norms. Our work includes the building of platforms and services and undertaking research developing predictors relating to health. Research: As biological research has become more data intensive, the breadth of data and expertise required to address research problems has expanded. It requires the integrated efforts of a distributed set of researchers (such as bench/data scientists, data engineers, project managers, administrators, governance experts, and clinical researchers) with shared interests and complementary resources. Effective collaboration depends on a collective ability to work together in trusted ways that lead to translatable biomedical insights. We call this scientific coordination. Sage's scientific coordination stack includes: 1) hypothesis and data generation, 2) data curation, 3) analysis, 4) interpretation, and 5) dissemination. We focus on building a federated network of individuals who bring diverse expertise and approaches to develop robust solutions. New research projects initiated in 2018 included: * Human Tumor Atlas Network (HTAN) - Funded by NCI, Sage is the data coordinating center for HTAN which aims to leverage the power of human genome sequencing and other state-of-the-art profiling technologies, to analyze changes in individual tumors. * VEOIBD Portal - Funded by the Helmsley Charitable Trust, the VEOIBD Portal aggregates Consortium-identified genotypic data with data from other data sources to find causes and treatments for Inflammatory Bowel Disease (IBD). Ongoing research communities included: * Agora - funded by the NIA, Agora is a platform that enables researchers to access information about how genes are associated with Alzheimer's disease. It aggregates lines of biological evidence from multiple sources, so researchers can better prioritize which genes they want to follow up on for development of new therapies. * All of Us - a program to engage over one million participants in a study to improve the ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics. * CD2H (National Center for Data to Health) - with aims to foster collaboration across more than 50 premier medical research institutions within the prestigious Clinical and Translational Science Awards, or CTSA, network. * Cancer Systems Biology Consortium (CSBC) - Sage serves as the Coordinating Center for the CSBC and Physical Sciences in Oncology Network (PS-ON) program. This five-year award builds on the work of the NCI funded Sage Bionetworks' Center for Cancer Systems Biology from 2010 through 2015. * iAtlas -together with the Institute for Systems Biology, Sage was funded by the Cancer Research Institute to build iAtlas, an online database and web resource designed to help basic and clinical researchers navigate immunological data across multiple tumor types. * KiAAP - funded by Bill and Melinda Gates Foundation, Sage was engaged to support the distributed efforts of BMGF funded data scientists across a number of ongoing research projects in neurocognitive development. * MODEL-AD Consortium - Sage runs the Knowledge Portal, the distribution site for data, analysis results, analytical methodology and research tools generated by the AMP-AD and M2OVE-AD Consortia. * Synodos Consortium - a first-of-its-kind Neurofibromatosis research collaboration dedicated to defeating the rare genetic disorder neurofibromatosis type 2. * The Cancer Genome Atlas (TCGA) - with data from 12 cancers, TCGA is an ongoing effort to simultaneously analyze molecular platforms for patterns across cancer types. * Tumor Neoantigen Selection Alliance (TESLA) - a global research alliance with 30 public and private groups to advance the development of more effective personalized cancer treatments. Funded by the Parker Institute for Cancer. Challenges: With algorithms playing an increasing role in biomedical analysis and patient care, there's a need for a more rigorous framework for evaluating and improving the capabilities of these algorithms. Sage Bionetworks has pioneered the development of concepts and infrastructure to objectively evaluate algorithms across a broad spectrum of biomedical domains, including bioinformatics, biomedical informatics, and clinical trials. As a trusted partner in hosting challenges and benchmarking initiatives, Sage serves as a broker between data generators and data modelers. We combine technology with biomedical and data science expertise to facilitate the objective assessment of algorithms on critical data sets, including proprietary data and algorithms that cannot be broadly shared. Sage works with the DREAM community to host open challenges. With 13 years of successful Challenges, DREAM is recognized as a leader in biomedical competitions, successfully motivating research teams to address fundamental questions about systems biology and translational medicine and to advance computational methods. DREAM challenges invite participants to propose solutions - fostering collaboration and building communities in the process. Over 20,000 people from around the world and across disciplines have contributed their expertise to Challenges. Sage Bionetworks provides institutional support, along with the infrastructure to host challenges via our Synapse platform Active Challenges hosted on the Synapse platform in 2018 included: * ACIC 2018 Causal Inference Challenge -held at the annual Atlantic Causal Inference Conference (ACIC), participants of this challenge focused on computational methods of inferring causal effects from real-world healthcare-related data. * DREAM Single Cell Transcriptomics Challenge - participants were asked to reconstruct the location of single cells in the Drosophila embryo using single-cell transcriptomic data. * IDG Drug-Kinase Binding Challenge - seeks to evaluate the power of statistical and machine learning models as a systematic and cost-effective means for catalyzing compound-target interaction mapping efforts. * Multi-targeting Drug DREAM Challenge - seeks to diversify the methods used for rational design of drugs with multiple target proteins.
Interesting data from their 2019 990 filing
The purpose of the non-profit is listed in the filing as “Sage bionetworks is a strategic research organization with a mission to coordinate and link academic and commercial biomedical researchers, patients and citizens through a commons that represents a new paradigm for genomics intellectual property, researcher cooperation and contributor evolved resources. this mission has several interdependent themes, including: conducting research on network models of disease; building the computational platform for the commons; and activating public engagement. sage bionetworks is a non-profit research organization that seeks to develop predictors of disease and accelerate health research through the creation of open systems, incentives, and standards. we create strategies and platforms that empower researchers to share and interpret data on a colossal scale, crowdsource tests for new hypotheses, and contribute to knowledge through community challenges.”.
When discussing its operations, they were characterized as: “Sage bionetworks is a strategic research organization with a mission to coordinate and link academic and commercial biomedical researchers, patients and citizens through a commons that represents a new paradigm for genomics intellectual property, researcher cooperation and contributor evolved resources. this mission has several interdependent themes, including: conducting research on network models of disease; building the computational platform for the commons; and activating public engagement.”.
- The non-profit's legally reported state of operation is WA.
- The filing states that the non-profit's address in the year 2019 is 2901 Third Ave, Seattle, WA, 98121.
- The form submitted by the non-profit for 2019 shows a total of 71 employees.
- Is not a private foundation.
- Expenses are greater than $1,000,000.
- Revenue is greater than $1,000,000.
- Revenue less expenses is $3,236,499.
- The organization has 5 independent voting members.
- The organization was formed in 2009.
- The organization pays $8,601,831 in salary, compensation, and benefits to its employees.
- The organization pays $40,673 in fundraising expenses.